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OwnerStanley N. Cohen, Daniel Rock +4inventors
InventorsStanley N. Cohen, Daniel Rock, Annie Chang, Yanan Feng, Laszlo Zsak, Maria Elisa Piccone
Estimating the term…
Methods and compositions for rapidly identifying CGEPs required for viral infection of mammalian cells are provided. Also provided are methods of inhibiting viral infection of mammalian cells by inhibiting the activity of one or more CGEPs (e.g., as identified in accordance with methods of the invention) in the cells. Aspects of the invention further include specifically identified CGEPs implicated in mammalian cell infection of specific viruses, e.g., African Swine Fever Virus and Foot and Mouth Virus, and methods of modulating their activity to achieve viral resistance.
A method of identifying a mammalian cellular gene exploited by a viral pathogen (CGEP), said method comprising:
A method of treating a subject suffering from a virally mediated disease condition, said method comprising:
A method of conferring a virally resistant phenotype on a subject, said method comprising:
A transgenic non-human mammal having a viral infection resistant phenotype that is conferred upon said mammal by a modification in a CGEP.
A system for identifying a mammalian cellular gene exploited by a viral pathogen (CGEP), said system comprising:
Dependencies are inferred from the claim text.