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AssigneeAbbott Laboratories
InventorsPradip Mukerji, Amanda Eun-Yeong Leonard, Yung-Sheng Huang, Suzette L. Pereira
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The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ω3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ω6-docosapentaenoic acid or ω3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
An isolated nucleic acid molecule comprising or complementary to a nucleotide sequence encoding a polypeptide having elongase activity, wherein the amino acid sequence of said polypeptide has at least 90% identity to an amino acid sequence comprising SEQ ID NO:121.
An isolated nucleic acid molecule comprising or complementary to a nucleotide sequence having at least 90% nucleotide sequence identity to a nucleotide sequence comprising SEQ ID NO:119, wherein the nucleotide sequence encodes a polypeptide with fatty acid elongase activity.
The nucleic acid molecule of claim 4 wherein said algae is Pavlova sp.
A plant cell, plant or plant tissue comprising a vector comprising:
A transgenic plant comprising a vector comprising:
A transgenic, non-human mammal whose genome comprises a DNA sequence encoding an elongase, operably linked to a promoter, wherein said DNA sequence comprises SEQ ID NO:119.
A method for producing a polyunsaturated fatty acid comprising the steps of:
Dependencies are inferred from the claim text.