Compounds which inhibit beta-secretase activity and methods of use thereof

A compound having the formula:

• wherein
• R1 is halogen, —OH, —CF3, —NO2, —N(R8)R9, —OR10, —S(O)nR11, —C(O)R12, hydrogen, substituted or unsubstituted C3-C20 alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or -L4-Y;
• R5 is halogen, —OH, —CF3, —NO2, —N(R8)R9, —OR10, —S(O)nR11, —C(O)R12, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 and R3 are independently halogen, —CF3, —NO2, —N(R8)R9, —OR10, —S(O)nR11, —C(O)R12, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or -L4-Y;
• R4 is halogen, —OH, —CF3, —NO2, —N(R8)R9, —OR10, —S(O)nR11, —C(O)R12, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or -L4-Y;
• R6 and R7 are independently —S(O)2R11, —C(O)R12, —N(R8)R9, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or -L4-Y;
• n is independently 0, 1, or 2;
• R8 is independently —C(O)R13, —S(O)2R14, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R9 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10 is independently —C(O)R13, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R11 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein if n is 2, then R11 is optionally —N(R15)R16, and wherein if n is 1 or 2, then R11 is not hydrogen;
• R12 is independently —N(R18)R19, —OR19, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R13 is independently —OR19, —N(R18)R19, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl,
• R14 is independently —N(R18)R19, hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein
• R18 and R19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R15 and R16 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L1 is —N(R17)—, —S(O)q—, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene;
• L2 is substituted or unsubstituted alkylene, —N(R17)—, —S(O)q—, or substituted or unsubstituted heteroalkylene;
• L3 is a bond, —N(R17)—, —S(O)q—, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene;
• R17 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• q is independently 0, 1, or 2;
• A1 is substituted or unsubstituted C5-C7 cycloalkyl, substituted or unsubstituted 5-7 membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• A2 is substituted or unsubstituted C5-C7 cycloalkyl, or substituted or unsubstituted 5-7 membered heterocycloalkyl;
• Y is a carrier moiety;
• and
• L4 is a bond, —OP(OH)2O—, —C(O)OR20—, —C(O)NHR21—, —S(O)2NHR22—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, or a peptidyl linker, wherein
• R20, R21, and R22 are independently substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or a pharmaceutically acceptable salt, prodrug, hydrate, racemate, diastereomer, tautomer, isotope, or crystalline form thereof.