Modulation of pathogenicity

A compound of Formula (I)

• or a pharmaceutically acceptable salt or physiologically functional derivative thereof;
• wherein
• A1 is furanyl, which may be optionally substituted with one or more R3;
• p is 0;
• Y1 is C(O) or C(S);
• R1 is H or alkyl, cycloalkyl, aryl, or heteroaryl, each of which may be optionally substituted with one or more R3;
• n is 1;
• R2 is H or alkyl, cycloalkyl, aryl, or heteroaryl, each of which may be optionally substituted with one or more R3;
• Y2 is —C(O)— or —C(S)—;
• A2 is alkyl, aryl, or heteroaryl, each optionally substituted with one or more R3;
• each R3 independently is OR4, SR4, hydroxyalkyl, hydroxyalkylamino, cycloalkyl, halogen, haloalkyl, haloalkoxy, NO2, CN, SO2NR4R5, CO2NR4R5, COR4, CO2R4, SO2R4, SO3R4, NR4R5, alkyl, aryl, aryl substituted with halogen, or heteroaryl;
• each R4 independently is H, alkyl, cycloalkyl, aryl, or heteroaryl;
• and
• each R5 independently is H, O-alkyl, O-aryl, alkyl, heteroaryl, or aryl.