Method of treating organism by biologically active compounds specifically delivered into mitochondria, pharmaceutical composition required for the use of the method and a compound applicable for this purpose

A pharmaceutical composition comprising therapeutically effective amount of a compound of Structure (I) for targeted delivery of biologically active substances into cellular mitochondria:

• wherein A—effector of structure:
• a) antioxidant (structure II)
• and/or reduced form thereof
• wherein m is an integer from 1 to 3;
• each Y is independently selected from the group consisting of:
• lower alkyl, lower alkoxy;
• or two adjacent Y groups, together with carbon atoms to which they are attached, form a following structure:
• and/or reduced form thereof
• wherein R1 and R2 may be the same or different and are each independently lower alkyl or lower alkoxy;
• with proviso that the antioxidant is able to react with enzymes of mitochondria respiratory chain in order to neutralize its radical form created by interaction with free radicals and reactive oxygen species, and to restore its original (fully reduced) form. It is preferable that the difference between minimal concentration having antioxidant action and minimal concentration having prooxidant action on mitochondria would be at least 10 fold;
• b) pro-oxidant;
• c) apoptosis inductor or inhibitor of anti-apoptosis protein of mitochondrial localization;
• g) photosensitizer;
• L—linker group, comprising:
• a) straight or branched hydrocarbon chain which can be optionally substituted by one or more substituents and optionally contains one or more double or triple bonds;
• b) natural isoprene chain;
• n is integer from 1 to 20;
• B—targeting group, comprising
• a) Skulachev-ion Sk:
• Sk+ Z−
• where Sk—lipophilic cation, Z—pharmacologically acceptable anion;
• b) charged hydrophobic peptide containing 1-20 amino acid residues;
• with proviso that in compound of structure (I) A is not ubiquinone (e.g. 2-methyl-4,5-dimethoxy-3,6-dioxo-1,4-cyclohexadienyl) or tocopherol or mimetic of superoxide dismutase or ebselen;
• while L—divalent decyl or divalent pentyl or divalent propyl radical;
• and while B is triphenylphosphonium cation;
• as well as solvates, isomers and prodrugs thereof;
• and pharmaceutically acceptable carrier.