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US 2008/0176923 A1Published application
Proline Derivatives Used as Pharmaceutical Active Ingredients for the Treatment of Tumors
OwnerZoser B. Salamainventor
Life of this patent
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Abstract
The invention relates to proline derivatives and their salts, to pharmaceutical agents containing said derivatives and to the use of said agents for treating tumours. The invention also relates to methods for producing said compounds and pharmaceutical agents.
Claims46
A compound of general formula (I),
- wherein
- R1 is a hydroxy, aryl or amino acid group,
- R2 is hydrogen, an alkyl (C1-C4), a substituted alkyl (C1-C4) group, a dialkyl (C1-C4), a cyclohexyl, a phenyl or diphenyl group,
- R3 is an alkyl (C2-C5) group, and/or salts thereof,
- with the proviso that, if R1 is a hydroxy group, R2 is not a methyl group, said compound being selected from the group comprising 4-hydroxy-1,1-dimethylproline ethyl ester iodide, 4-hydroxyproline isobutyl ester, 4-hydroxy-1,1-dimethylproline isobutyl ester iodide, 4-hydroxy-1-cyclohexylproline isobutyl ester, 4-hydroxyl-1-diphenylmethylproline isobutyl ester hydrobromide, 4-hydroxy-1-methylproline ethyl ester, 4-hydroxy-1-methylproline isobutyl ester and/or 1-methyl-4-phenylaminocarbonyloxyproline isobutyl ester, and, if R1 is a hydroxy group, said compounds may have a methyl group in position R2.
2 more elements
(canceled)
Method for the diagnosis, prophylaxis, follow-up, therapy, and/or aftercare of a disease associated with cell growth, cell differentiation and/or cell division, comprising
- administering to a person in need thereof and/or benefiting therefrom 4-hydroxyproline ethyl ester, 4-hydroxy-1,1-dimethylproline ethyl ester iodide, 4-hydroxyproline isobutyl ester, 4-hydroxy-1,1-dimethylproline isobutyl ester iodide, 4-hydroxy-1-cyclohexylproline isobutyl ester, 4-hydroxy-1-diphenylmethylproline isobutyl ester hydrobromide, 4-hydroxy-1-methylproline, 4-hydroxy-1-methylproline ethyl ester, 4-hydroxy-1-methylproline isobutyl ester, 1-methyl-4-phenylaminocarbonyloxyproline, 1-methyl-4-phenylaminocarbonyloxyproline isobutyl ester, (R)-(+)-α,α-diphenyl-2-pyrrolidinemethanol and/or (S)-(−)-α,α-diphenyl-2-pyrrolidinemethanol and/or derivatives, metabolites, enantiomers and/or isomers thereof in a diagnosis, prophylaxis, follow-up, therapy, and/or aftercare of diseases associated with cell growth, cell differentiation and/or cell division effective amount, wherein said disease is a tumor.
(canceled)
Dependencies are inferred from the claim text.