Uses of 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssris

A method of treating a disease or disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I:

• wherein the sulphur atom is attached to the indole via any ring carbon of the indole and wherein
• R1-R2 are independently selected from hydrogen, C1-4-alk(en/yn)yl, C3-8-cycloalk(en)yl, and C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl or R1 and R2 together with the nitrogen form a 4-7 membered ring containing zero or one double bond, optionally said ring in addition to said nitrogen comprises one further heteroatom selected from nitrogen, oxygen and sulphur;
• R3-R7 and R9-R12 are independently selected from hydrogen, halogen, cyano, nitro, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, amino, C1-6-alk(en/yn)ylamino, di-(C1-6-alk(en/yn)yl)amino, C1-6-alk(en/yn)ylcarbonyl, aminocarbonyl, C1-6-alk(en/yn)ylaminocarbonyl, di-(C1-6-alk(en/yn)yl)aminocarbonyl, hydroxy, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylthio, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)ylsulfonyl, halo-C1-6-alk(en/yn)ylsulfanyl and C1-6-alk(en/yn)ylsulfonyl;
• R8 is halogen;
• and
• R13 is selected from hydrogen or C1-6-alk(en/yn)yl;
• or a pharmaceutically acceptable salt thereof;
• with the provisos that:
• when the sulphur atom is attached via atom nr. 2 of the indole then R7 does not exist;
• when the sulphur atom is attached via atom nr. 3 of the indole then R12 does not exist;
• when the sulphur atom is attached via atom nr. 4 of the indole then R8 does not exist;
• when the sulphur atom is attached via atom nr. 5 of the indole then R9 does not exist;
• when the sulphur atom is attached via atom nr. 6 of the indole then R10 does not exist;
• and
• when the sulphur atom is attached via atom nr. 7 of the indole then R11 does not exist.

A method of treating a disease or disorder comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of:

• [2-(4-Fluoro-1H-indol-3-ylsulfanyl)benzyl]dimethyl amine;
• [2-(4-Chloro-1H-indol-3-ylsulfanyl)benzyl]dimethyl amine;
• [2-(4-Chloro-1H-indol-3-ylsulfanyl)benzyl]methyl amine;
• [2-(4-Fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine;
• [2-(4-Bromo-1H-indol-3-ylsulfanyl)-benzyl]methyl amine;
• [5-Fluoro-2-(4-fluoro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
• [2-(4-Chloro-1H-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine;
• [2-(4-Bromo-1H-indol-3-ylsulfanyl)-5-fluoro-benzyl]-methyl-amine;
• [2-(4-Fluoro-1H-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine:
• [4-Chloro-2-(4-fluoro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
• [4-Chloro-2-(4-chloro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
• [2-(4,5-Difluoro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
• [2-(4,6-Difluoro-1H-indol-3-ylsulfanyl)-benzyl]-methyl-amine;
• and
• [2-(4-Chloro-1H-indol-3-ylsulfanyl)-5-methyl-benzyl]-methyl-amine;
• or a pharmaceutically acceptable salt thereof.