A-amino-n-hydroxy-acetamide derivatives
AssigneeNovartis AG
InventorsKenji Hayakawa, Genji Iwasaki, Shinichi Koizumi, Ichiro Umemura
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Abstract
The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula I, wherein R is di-lower alkyl amino, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl or 1,2,4-triazol-4-yl, m represents an integer from 1 up to and including 10, and n represents an integer from 0 up to and including 10, and salts thereof: to processes for their preparation, pharmaceutical compositions comprising said hydroxamic acid derivatives, the use of such hydroxamic acid derivatives as medicaments, and a method of treating conditions or diseases mediated by matrix-degrading metalloproteinases (MMP's) using said derivatives alone or in combination with one or more other therapeutic agents.
Claims10
An α-amino-N-hydroxy-acetamide derivative of the formula I,
- wherein
- R is 1,2,3-triazol-2-yl,
- m is 1 or 2 and
- n is 1 or 2,
- or a salt thereof.
2-4. (canceled)
A process for the preparation of an a-amino acetyl hydroxamic acid derivative of the formula I,
- wherein R is 1,2,3-triazol-2-yl, m is 1 or 2, and n is 1 or 2 or a salt thereof, which comprises reacting a carbonic acid of the formula II
- wherein R, m and n have reagent which is capable of transforming the carbonic acid into the corresponding acyl halide, in the presence of a suitable catalyst, and then with NH2OH in a suitable solvent or mixture of solvents, and for the preparation of a salt, converting a resulting free compound of the formula I into a salt or, if necessary for preparation of a free compound, converting a resulting salt of a compound of the formula I into the free compound.
A compound of formula II,
- wherein R is 1,2,3-triazol-2-yl, m is 1 or 2, and n is 1 or 2, or a salt thereof,
- or a salt thereof.
Dependencies are inferred from the claim text.