Acylaminothiazole derivatives and use thereof as beta-amyloid inhibitors

A compound having the general formula (I):

• in which
• R1 represents either a C1-6 alkyl optionally substituted by one to three substituents selected from halogen, trifluoromethyl, hydroxyl, C1-6 alkoxy, C1-6 thioalkyl, thiophene and phenyl;
• or a C3-7 cycloalkyl, or a thiophene, or a benzothiophene, or a pyridinyl, or a furanyl or a phenyl;
• the said phenyl groups being optionally substituted by one to three substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, hydroxyl, methylenedioxy, phenoxy, benzyloxy and trifluoromethyl;
• R2 and R′2 represent, independently of one another, a substituent selected from hydrogen, halogen, hydroxyl, C1-3 alkoxy, C1-3 alkyl, C3-7 cycloalkyl and O—C(O)—C1-6 alkyl group, or R2 and R′2 together form an oxo group;
• R3 represents either hydrogen or C1-6 alkyl optionally substituted by hydroxyl, C1-6 cycloalkyl or C1-3 alkoxy;
• R4 is Z and R5 is L or R4 is L and R5 is Z;
• wherein the group L is:
• in which G represents a C1-7 alkyl or a single bond;
• M represents a C3-7 cycloalkyl, a phenyl, a naphthyl or a pyridinyl, the group M being optionally substituted by one or more groups selected from halogen, hydroxyl, C1-3 alkyl, C1-3 alkoxy, trifluoromethyl, trifluoromethoxy and —O—CBF2;
• and
• J represents hydrogen or a group —Y—K;
• wherein
• Y represents a single bond, oxygen, sulphur, —C1-4 alkylene-, —O—C1-4 alkylene- or —C1-4 alkylene-O— or a group —N(W)—, the —C1-4 alkylene- being optionally substituted by a hydroxyl or C1-3 alkoxy;
• W represents either hydrogen, C1-3 alkyl optionally substituted by phenyl, or phenyl;
• and
• K represents a phenyl or pyridinyl group, the group K being optionally substituted by one or more groups selected from halogen, hydroxyl, C1-3 alkyl, C1-3 alkoxy, trifluoromethyl, trifluoromethoxy and —O—CHF2;
• Z represents CN, SO2NR6R7 or a heteroaromatic group, the said heteroaromatic group being optionally substituted by a group R;
• R8 representing either a C1-4 alkyl which is itself optionally substituted by a CN, a phenyl or a phenoxy;
• or a phenyl;
• the said phenyl and phenoxy groups being optionally substituted by 1 to 3 groups selected from halogen, C1-3 alkyl, C1-3 alkoxy and trifluoromethyl;
• and
• R6 and R7 represent, independently of one another, either hydrogen, or C1-6 alkyl optionally substituted by C3-7 cycloalkyl, C3-7 cycloalkenyl, C1-3 alkoxy, phenyl, naphthalenyl, morpholinyl or pyridinyl;
• or C3-7 cycloalkyl, C1-6 alkoxy, phenyl or indanyl;
• the said C3-7 cycloalkyl, C3-7 cycloalkenyl, phenyl, naphthalenyl, morpholinyl, pyridinyl and indanyl groups being optionally substituted by one or two groups selected from C1-3 alkyl, hydroxyl, C1-3 alkoxy, phenyl or halogen;
• or
• R6 and R7, together with the nitrogen atom to which they are attached, form an aziridine, azetidine, pyrrolidine, piperidine, morpholine or benzopiperidine ring;
• or
• said compound in the form of a salt, or a hydrate or a solvate of said compound or said salt.