NOS Inhibitors For Treatment Of Motor Deficit Disorders
AssigneeNorthwestern University
InventorsRichard B. Silverman, Haitao Ji, Sidhartha Tan, Matthew Derrick
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Abstract
The present invention relates to preventive therapies and treatments of motor deficit disorders. In particular, the present invention relates to compositions and methods for preventative therapy and treatment of motor deficit disorders, such as cerebral palsy, in fetuses and newborn infants using inhibitors to neuronal nitric oxide synthase (nNOS).
Claims19
A method of preventing a motor deficit disorder in a fetus or newborn infant by administering to a pregnant subject, or to the fetus or newborn, a neuronal nitric oxide synthase inhibitor.
Use of a neuronal nitric oxide synthase inhibitor for the manufacture of a medicament for use in the treatment of a fetus or newborn, by administration to a pregnant subject or to a fetus or newborn, of a motor deficit disorder.
A pharmaceutical composition comprising a neuronal nitric oxide synthase inhibitor and a second compound, said second compound comprising an agent useful for treatment of a motor deficit disorder that is not a nitric oxide synthase inhibitor.
Dependencies are inferred from the claim text.