5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS
AssigneeTianjin Hemay Bio-Tech Co., Ltd.
InventorHesheng ZHANG
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Abstract
Taught are derivatives of 5H-thioeno(3,4-c)pyrrole-4,6-dione, their organic, and inorganic salts, methods of synthesis of these derivatives, and their application as active pharmaceutical-ingredients useful as inhibitors of TNFα, the derivative being represented by the general formula (I): in which R1 represents H, C1-6alkyl, OR4, OC(O)R5, NO2, NHC(O)R6, or NR7R8; R2 represents H, a halogen, or C1-6alkyl; R3 represents H, methyl, isopropyl, allyl, benzyl, CH2CO2(C1-6alkyl), or CH2(CH2)nR9; R4, R5, R6, R7, and R8 each independently and at each occurrence represents H, or C1-6alkyl; R9 represents H, C1-6alkyl, OH, OC1-6alkyl, NH2, NHC1-6alkyl, N(C1-6alkyl)2, or CO2(C1-6alkyl); and n represents 1, 2, 3, or 4.
Claims10
A 5H-thioeno(3,4-c)pyrrole-4,6-dione derivative represented by formula (I)
- an organic salt thereof, or an inorganic salt thereof, wherein
- R1 represents H, C1-6alkyl, OR4, OC(O)R5, NO2, NHC(O)R6, or NR7R8;
- R2 represents H, a halogen, or C1-6alkyl;
- R3 represents H, methyl, isopropyl, allyl, benzyl, CH2CO2 (C1-6alkyl), or CH2(CH2)nR9;
- R4, R5, R6, R7, and R8 each independently and at each occurrence represent H, or C1-6 alkyl;
- R9 represents H, C1-6alkyl, OH, C1-6alkyloxy, NH2, C1-6 alkylamino, N(C1-6alkyl)2, or CO2(C1-6alkyl);
- and
- n represents 1, 2, 3, or 4.
Dependencies are inferred from the claim text.