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US 2008/0176898 A1Published application
Phenyl Acetamides
AssigneeBayer HealthCare LLC
InventorsMichael Harter, Frank Wunder, Lars Barfacker, Gunter Karig, Walter Hubsch, Hanna Tinel, Eva-Maria Becker
Life of this patent
Estimating the term…
Abstract
The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.
Claims14
A compound of the formula
- in which
- A is a 4- to 7-membered nitrogen-containing saturated heterocycle which is bonded via the nitrogen atom to the keto group,
- or
- is a radical
- in which
- E is (C4-C7)-cycloalkanediyl or (C1-C6)-alkanediyl,
- R3 is hydrogen or methyl and
- * is the point of linkage to the keto group,
- n is 0, 1 or 2,
- R1 is hydrogen or (C1-C6)-alkyl,
- R2 is hydrogen or (C1-C6)-alkyl,
- and
- Z is located in the meta or para position and
- is a radical *-G-L-M-R4
- in which
- G is O,
- L is (C1-C6)-alkanediyl,
- M is a bond or O,
- R4 is (C6-C10)-aryl, biphenyl, phenoxyphenyl, benzyloxyphenyl, (E)-phenylvinylphenyl, 2-phenylethylphenyl, tetrahydronaphthyl, benzyl, heteroaryl, 5- to 10-membered heterocyclyl, (C3-C7)-cycloalkyl or (C3-C7)-cycloalkylmethyl, where aryl, biphenyl, phenoxyphenyl, benzyloxyphenyl, (E)-phenylvinylphenyl, 2-phenylethylphenyl, tetrahydronaphthyl, benzyl, heteroaryl, heterocyclyl, cycloalkyl and cycloalkylmethyl in turn may be substituted up to three times independently of one another by halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C2-C6)-alkenyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkylmethoxy, (C5-C7)-cycloalkenyl, (C3-C7)-cycloalkoxy or (C5-C7)-cycloalkenyloxy, and
- * is the point of linkage to the phenyl ring,
- or a salt, solvate, or solvate of a salt thereof.
18 more elements
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.