N-[(4,5-diphenylpyrimidin-2-yl)methyl]amine derivatives, the preparation thereof and their therapeutic use

A compound of formula (I):

• in which:
• X represents a group
• R1 represents:
• a (C1-C12)-alkyl, unsubstituted or substituted one or more times with substituents selected independently from a fluorine atom, a hydroxyl, a (C1-C4)-alkoxy, a (C1-C4)-alkylthio, a phenoxy, a trifluoromethoxy radical, a difluoromethoxy radical, a difluoromethylthio radical or a trifluoromethylthio radical;
• a non-aromatic (C3-C12)-carbocyclic radical, unsubstituted or substituted one or more times with substituents selected independently from a (C1-C4)-alkyl, a (C1-C4)-alkoxy, a fluorine atom, a hydroxyl, a trifluoromethyl radical, a trifluoromethoxy radical or a (C1-C4)-alkylthio;
• a (C3-C7)-cycloalkylmethyl, unsubstituted or substituted one or more times on the cycloalkyl with substituents selected independently from a (C1-C4)-alkyl, a (C1-C4)-alkoxy, a fluorine atom, a hydroxyl, a trifluoromethyl radical or a trifluoromethoxy radical;
• a phenyl, unsubstituted or substituted one or more times with substituents selected independently from a halogen atom, a hydroxyl, an Alk group, an OAlk group, a methylenedioxy, a (C1-C4)-alkylamino, a di-(C1-C4)-alkylamino, a cyano, a nitro, an S(O)nAlk group, an OS(O)nAlk group, a (C1-C4)-alkylcarbonyl group;
• or from a phenyl, phenoxy, pyrrolyl, imidazolyl, pyridyl or pyrazolyl radical, said radical being unsubstituted or substituted one or more times with a (C1-C4)-alkyl;
• a benzyl, unsubstituted or substituted one or more times on the phenyl with substituents selected independently from a halogen atom, an Alk group, a hydroxyl, an OAlk group, a methylenedioxy, an S(O)nAlk group or an OS(O)nAlk group and unsubstituted or substituted on alpha-methyl by one or two similar or dissimilar groups selected from a (C1-C4)-alkyl, a (C3-C7)-cycloalkyl;
• a phenethyl, unsubstituted or substituted one or more times on the phenyl with substituents selected independently from a halogen atom, a (C1-C4)-alkyl, a (C1-C4)-alkoxy, a trifluoromethyl radical or a trifluoromethoxy radical;
• a benzhydryl or a benzhydrylmethyl;
• a 1,2,3,4-tetrahydronaphthalenyl, unsubstituted or substituted one or more times with a (C1-C4)-alkyl;
• or
• an aromatic heterocyclic radical selected from pyrrolyl, imidazolyl, furyl, thienyl, pyrazolyl, oxazolyl, pyridyl, indolyl, said radical being unsubstituted or substituted one or more times with substituents selected independently from a halogen atom, a (C1-C4)-alkyl, a (C1-C4)-alkoxy, a trifluoromethyl radical, a trifluoromethoxy radical, a cyano, a nitro or a (C1-C4)-alkylthio;
• R2 represents a hydrogen atom or a (C1-C3)-alkyl;
• R3 represents a hydrogen atom or a (C1-C5)-alkyl;
• R4 represents a phenyl, unsubstituted or substituted one or more times with substituents selected independently from a halogen atom, Alk group, OAlk group, S(O)nAlk group or OS(O)nAlk group;
• R5 represents a phenyl, unsubstituted or substituted one or more times with substituents selected independently from a halogen atom, Alk group, OAlk group, S(O)nAlk group or OS(O)nAlk group;
• R6 represents a hydrogen atom or a (C1-C3)-alkyl;
• n represents 0, 1 or 2;
• and
• Alk represents a (C1-C4)-alkyl, unsubstituted or substituted one or more times with a fluorine atom;
• with the proviso that R4 and R5 do not simultaneously represent a phenyl substituted with a (C1-C4)-alkoxy.