New Compounds 617

A compound according to formula I:

• wherein
• A is selected from phenyl and heteroaryl, wherein said phenyl or heteroaryl is optionally substituted with one or more R3;
• B is selected from hydrogen, halo, cyano, phenyl, heteroaryl, heterocyclyl, C3-6cycloalkyl, C3-6cycloalkenyl, C1-6alkyl, C2-6alkenyl, C0-6alkylC3-6cycloalkyl, and C2-6alkenylC3-6cycloalkyl, wherein said phenyl, heteroaryl, heterocyclyl, C3-6cycloalkyl, C3-6cycloalkenyl, C1-16alkyl, C2-6alkenyl, C0-6alkylC3-6cycloalkyl or C2-6alkenylC3-6cycloalkyl, is optionally substituted with one or two R4;
• C is selected from phenyl, heteroaryl and heterocyclyl, wherein said phenyl, heteroaryl or heterocyclyl is optionally substituted with one or two R5;
• R1 and R2 is OSO2R6;
• R3 is selected from halo and cyano;
• R4 is selected from halo, C1-6alkyl, methoxy, cyano, acetyl and trifluoromethoxy;
• R5 is selected from halo, C1-6alkyl, methoxy, trifluoromethyl, difluoromethoxy and trifluoromethoxy;
• or two R5 may together form a 2,3-dihydro-1,4-benzodioxine;
• R6 is selected from C1-6alkyl, C3-6cycloalkyl, trifluoromethyl, aryl, heteroaryl and N(CH3)2;
• said aryl being optionally fused with a 5 or 6 membered cyclyl or heterocyclyl group to form a bicyclic ring system;
• and said C1-6alkyl, C3-6cycloalkyl, aryl, heteroaryl, or bicyclic ring system is optionally substituted with one or more halogen, CN, NH2, OH, COOH, OC1-6alkyl, C1-6alkylOH, SO2H, C1-6alkyl, C(O)C1-6alkyl, C(O)OC1-6alkyl, C(O)NH2, C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)2, SO2C1-6alkyl, SO2NHC1-6alkyl, SO2N(C1-6alkyl)2, NH(C1-6alkyl), N(C1-6alkyl)2, NHC(O)C1-6alkyl, NC(O)(C1-6alkyl)2, aryl, Oaryl, C(O)aryl, C(O)Oaryl, C(O)NHaryl, C(O)N(aryl)2, SO2aryl, SO2NHaryl, SO2N(aryl)2, NH(aryl), N(aryl)2, NC(O)aryl, NC(O)(aryl)2, heteroaryl, Oheteroaryl, C(O)heteroaryl, C(O)Oheteroaryl, C(O)NHheteroaryl, C(O)N(heteroaryl)2, SO2heteroaryl, SO2NHheteroaryl, SO2N(heteroaryl)2, NH(heteroaryl), N(heteroaryl)2, NC(O)heteroaryl, NC(O)(heteroaryl)2, C5-6heterocyclyl, OC5-6heterocyclyl, C(O)C5-6heterocyclyl, C(O)OC5-6heterocyclyl, C(O)NHC5-6heterocyclyl, C(O)N(C5-6heterocyclyl)2, SO2C5-6heterocyclyl, SO2NHC5-6heterocyclyl, SO2N(C5-6heterocyclyl)2, NH(C5-6heterocyclyl), N(C5-6heterocyclyl)2, NC(O)C5-6heterocyclyl or NC(O)(C5-6heterocyclyl)2;
• R7 is C1-6alkyl optionally substituted with halogen, CN, NH2, OH, COOH, OC1-6alkyl, SO2H, C(O)C1-6alkyl, C(O)OC1-6alkyl, C(O)NH2, C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)2, SO2C1-6alkyl, SO2NHC1-6alkyl, SO2N(C1-6alkyl)2, NH(C1-6alkyl), N(C1-6alkyl)2, NHC(O)C1-6alkyl, NC(O)(C1-6alkyl)2, aryl, Oaryl, C(O)aryl, C(O)Oaryl, C(O)NHaryl, C(O)N(aryl)2, SO2aryl, SO2NHaryl, SO2N(aryl)2, NH(aryl), N(aryl)2, NC(O)aryl, NC(O)(aryl)2, heteroaryl, Oheteroaryl, C(O)heteroaryl, C(O)Oheteroaryl, C(O)NHheteroaryl, C(O)N(heteroaryl)2, SO2heteroaryl, SO2NHheteroaryl, SO2N(heteroaryl)2, NH(heteroaryl), N(heteroaryl)2, NC(O)heteroaryl, NC(O)(heteroaryl)2, C5-6heterocyclyl, OC5-6heterocyclyl, C(O)C5-6heterocyclyl, C(O)OC5-6heterocyclyl, C(O)NHC5-6heterocyclyl, C(O)N(C5-6heterocyclyl)2, SO2C5-6heterocyclyl, SO2NHC5-6heterocyclyl, SO2N(C5-6heterocyclyl)2, NH(C5-6heterocyclyl), N(C5-6heterocyclyl)2, NC(O)C5-6heterocyclyl, NC(O)(C5-6heterocyclyl)2;
• m=0 or 1;
• n=0 or 1;
• wherein one of m or n is at least 1;
• provided that the following compounds are excluded:
• 4-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl trifluoromethanesulfonate;
• 3′-(2-Amino-1-methyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-4-yl)biphenyl-3-yl trifluoromethanesulfonate;
• 3′-(2-Amino-1-methyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-4-yl)-5-methoxybiphenyl-2-yl trifluoromethanesulfonate;
• 3-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl trifluoromethanesulfonate;
• 3-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(5′-chloro-2′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-cyanobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-{2-Amino-1-methyl-5-oxo-4-[3′-(trifluoromethoxy)biphenyl-3-yl]-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[3-(2-chloropyridin-4-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-cyanobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(2′,5′-dimethoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(2′-fluoro-3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(2′-fluoro-5′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(3′-cyano-4′-fluorobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(5′-cyano-2′-fluorobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(2-fluoropyridin-4-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(2-chloro-3-fluoropyridin-4-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(2-chloro-5-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(2,6-difluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-{2-Amino-4-[3-(5-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(4′-fluoro-3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-1-methyl-5-oxo-4-(3-pyrazin-2-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 3′-(2-Amino-1-methyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-4-yl)-5-methoxybiphenyl-3-yl methanesulfonate;
• 4-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 3-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl trifluoromethanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl trifluoromethanesulfonate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl trifluoromethanesulfonate;
• 4-[2-Amino-4-(3′,5′-dichlorodiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 3-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 3-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 3-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 3-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 3-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 3-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-2-sulfonate;
• 3-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-2-sulfonate;
• 3-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-2-sulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-2-sulfonate;
• 3-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl dimethylsulfamate;
• 3-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl dimethylsulfamate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl dimethylsulfamate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-2-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-2-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-2-sulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-2-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-2-sulfonate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl dimethylsulfamate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-2-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl dimethylsulfamate;
• 3-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-2-sulfonate;
• 3′-(2-Amino-1-methyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-4-yl)-5-methoxybiphenyl-3-yl trifluoromethanesulfonate;
• 4-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(3′-cyano-6-fluorobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-cyano-6-fluorobiphenyl-3-yl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(2′,6-difluoro-3′-methoxybiphenyl-3-yl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(2′,6-difluoro-5′-methoxybiphenyl-3-yl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-cyano-4′,6-difluorobiphenyl-3-yl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(5′-cyano-2′,6-difluorobiphenyl-3-yl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(4-fluoro-3-pyridin-3-ylphenyl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-{2-Amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate (racemate);
• 4-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)-4-fluorophenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[4-fluoro-3-(6-fluoropyridin-3-yl)phenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[4-fluoro-3-(2-fluoropyridin-4-yl)phenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[3-(2-chloro-3-fluoropyridin-4-yl)-4-fluorophenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[3-(2-chloro-5-fluoropyridin-3-yl)-4-fluorophenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[3-(2,6-difluoropyridin-3-yl)-4-fluorophenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[6-fluoro-3′-(trifluoromethoxy)biphenyl-3-yl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-chloro-6-fluorobiphenyl-3-yl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(4-fluoro-3-pyridin-4-ylphenyl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(4-fluoro-3-pyrimidin-5-ylphenyl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-{2-Amino-4-[3-(2-chloro-5-methoxypyridin-3-yl)-4-fluorophenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-{2-Amino-4-[4-fluoro-3-(5-fluoropyridin-3-yl)phenyl]-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• 4-[2-Amino-4-(4-fluoro-3-pyrazin-2-ylphenyl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(4-fluoro-3-pyrazin-2-ylphenyl)-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-1-sulfonate;
• 4-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl propane-2-sulfonate;
• 4-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl dimethylsulfamate;
• 4-(2-Amino-4-{3′-methoxy-5′-[(methylsulfonyl)oxy]biphenyl-3-yl}-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl propane-1-sulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl trifluoromethanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl dimethylsulfamate;
• 4-(2-Amino-4-{6-fluoro-3′-methoxy-5′-[(methylsulfonyl)oxy]biphenyl-3-yl}-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl methanesulfonate;
• 3-(2-Amino-1-methyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-4-yl)phenyl methanesulfonate;
• 3-(2-Amino-1-methyl-5-oxo-4-phenyl-4,5-dihydro-1H-imidazol-4-yl)phenyl trifluoromethanesulfonate;
• 3′-(2-Amino-1-methyl-5-oxo-4-pyridin-4-yl-4,5-dihydro-1H-imidazol-4-yl)-5-methoxybiphenyl-3-yl methanesulfonate;
• 3′-(2-Amino-1-methyl-5-oxo-4-pyridin-2-yl-4,5-dihydro-1H-imidazol-4-yl)-5-methoxybiphenyl-3-yl methanesulfonate;
• 3′-[2-Amino-4-(3-furyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]-5-methoxybiphenyl-3-yl methanesulfonate;
• 3′-[2-Amino-1-methyl-5-oxo-4-(1,3-thiazol-5-yl)-4,5-dihydro-1H-imidazol-4-yl]-5-methoxybiphenyl-3-yl methanesulfonate;
• 3′-[2-Amino-1-methyl-5-oxo-4-(1,3-thiazol-4-yl)-4,5-dihydro-1H-imidazol-4-yl]-5-methoxybiphenyl-3-yl methanesulfonate;
• 4-[2-Amino-4-(5′-fluoro-2′-methylbiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 4-[2-Amino-4-(3′-cyanobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-4-(2′,5′-dimethoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-4-(2′-fluoro-3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-4-(2′-fluoro-5′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-4-(3′-cyano-4′-fluorobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-4-(5′-cyano-2′-fluorobiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 4-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 4-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-{2-Amino-4-[3-(2-chloro-3-fluoropyridin-4-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 4-{2-Amino-4-[3-(2-chloro-5-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 4-{2-Amino-4-[3-(2,6-difluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 4-{2-Amino-4-[3-(5-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-4-(4′-fluoro-3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-1-methyl-5-oxo-4-(3-pyrazin-2-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl ethanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 3-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 3-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 3-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyridin-3-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl cyclopropanesulfonate;
• 3-{2-Amino-4-[3-(6-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl cyclopropanesulfonate;
• 3-{2-Amino-4-[3-(2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl cyclopropanesulfonate;
• 3-{2-Amino-4-[3-(5-chloro-2-fluoropyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl cyclopropanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-5-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl cyclopropanesulfonate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl 2-methoxyethanesulfonate;
• 3-{2-Amino-4-[3-(5-methoxypyridin-3-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl cyclopropanesulfonate;
• 3-[2-Amino-1-methyl-5-oxo-4-(3-pyrimidin-2-ylphenyl)-4,5-dihydro-1H-imidazol-4-yl]phenyl cyclopropanesulfonate;
• 3-[2-Amino-4-(4-methoxyphenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 3-methoxypropane-1-sulfonate;
• 3-[2-Amino-4-(4-methoxyphenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate;
• 3-[2-Amino-4-(4-methoxyphenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-ethoxyethanesulfonate;
• 3-[2-Amino-4-(4-methoxyphenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• 4-[2-Amino-4-(3′-methoxybiphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl 2-methoxyethanesulfonate;
• and
• 4-{2-Amino-4-[3-(1H-indol-5-yl)phenyl]-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl}phenyl methanesulfonate;
• as a free base or a pharmaceutically acceptable salt, solvate or solvate of a salt thereof.