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US 2008/0176859 A1Published application
Heterocyclyamide-substituted imidazoles
AssigneeAiCuris GmbH & Co. KG
InventorsHolger ZIMMERMANN, David BRUECKENER, Kerstin HENNINGER, Ulrich ROSENTRETER, Martin HENDRIX, Joerg KELDENICH, Dieter LANG, Martin RADTKE, Daniela PAULSEN, Armin KERN
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Abstract
The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.
Claims20
A compound of formula
- in which
- R1 represents a group of formula
- whereby
- * represents the linkage site to the carbonyl group,
- R4 represents phenyl or 5- or 6-membered heteroaryl,
- wherein phenyl and heteroaryl may be substituted with 1 to 3 substituents, whereby the substituents are selected independently of one another from the group consisting of halogen, hydroxy, oxo, nitro, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, aminocarbonyl and C1-C6-alkylaminocarbonyl,
- R5 represents phenyl or 5- or 6-membered heteroaryl,
- wherein phenyl and heteroaryl may be substituted with 1 to 3 substituents, whereby the substituents are selected independently of one another from the group consisting of halogen, hydroxy, oxo, nitro, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, aminocarbonyl and C1-C6-alkylaminocarbonyl,
- and
- R6 and R7 independently of one another represent hydrogen, methyl or ethyl,
- R2 represents C1-C6-alkyl,
- whereby alkyl may be substituted with a substituent, whereby the substituent is selected from the group consisting of C3-C6-cycloalkyl, C6-C10-aryl and 5- or 6-membered heteroaryl,
- wherein cycloalkyl, aryl and heteroaryl may be substituted with 1 to 3 substituents, whereby the substituents are selected independently of one another from the group consisting of halogen, hydroxy, oxo, nitro, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, C1-C6-alkoxycarbonyl, amino, C1-C6-alkylamino, aminocarbonyl and C1-C6-alkylaminocarbonyl,
- R3 represents phenyl,
- whereby phenyl may be substituted with 1 to 3 substituents, whereby the substituents are selected independently of one another from the group consisting of halogen, hydroxy, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, monofluoromethoxy, trifluoromethylthio, C1-C6-alkyl and C1-C6-alkoxy,
- or one of its salts, its solvates or the solvates of its salts.
13 more elements
Dependencies are inferred from the claim text.