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US 2008/0176855 A1Published application
Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics
AssigneeSanofi-Aventis
InventorsFrederic GALLI, Odile LECLERC, Alistair LOCHEAD, Julien VACHE
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Abstract
The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
Claims25
A compound of formula (I):
- in which:
- R is
- either a hydrogen or halogen atom;
- or a phenyl group optionally substituted with one or more halogen atoms, or with one or more groups selected from (C1-C6)alkyl, (C1-C6)alkoxy, nitro, amino, di(C1-C3)alkylamino, trifluoromethyl, trifluoromethoxy, cyano, hydroxyl, acetyl or methylenedioxy groups;
- or a group selected from pyridinyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, thienyl, furyl, isoxazolyl, isothiazolyl, pyrrolyl and naphthyl, it being possible for this group to be optionally substituted with one or more groups selected from halogen atoms, and (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethoxy, trifluoromethyl, nitro, cyano, hydroxyl, amino, (C1-C6)alkylamino or di(C1-C6)alkylamino groups;
- or an acid addition salt thereof, or a hydrate or a solvate thereof.
3 more elements
Dependencies are inferred from the claim text.