Triazine derivatives and their therapeutical applications

A compound of the formula

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 represents hydrogen, halogen, hydroxy, amino, cyano, alkyl, cycloalkyl, alkenyl, alkynyl, alkylthio, aryl, arylalkyl, heterocyclic, heteroaryl, heterocycloalkyl, alkylsulfonyl, alkoxycarbonyl and alkylcarbonyl;
• R2 is selected from:
• (ii) amino, alkyl amino, aryl amino, heteroaryl amino;
• (ii) C1-C6 allyl, C2-C6 alkenyl, C2-C6 alkynyl;
• (iii) heterocyclic, heteroaryl;
• and
• (iv) groups of the formula (Ia):
• wherein:
• X is CH, when R4 is hydrogen;
• or X—R4 is 0;
• or X is N when R4 represents groups,
• R3 is hydrogen, C1-C4 alkyl, oxo;
• R4 is chosen from:
• (a) hydrogen, C1-C6 allyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 aryl or heteroaryl, (C3-C7cycloalkyl)C1-C4allyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 alkylthio, C2-C6 alkanoyl, C1-C6 alkoxycarbonyl, C2-C6 alkanoyloxy, mono- and di-(C3-C8 cycloalkyl)aminoC0-C4allyl, (4- to 7-membered heterocycle)C0-C4allyl, C1-C6 alkylsulfonyl, mono- and di-(C1-C6 alkyl) sulfonamido, and mono- and di-(C1-C6allyl)aminocarbonyl, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxy, cyano, amino, —COOH and oxo;
• L is selected from O, CO, (CH2)m, m=0-3, NR1, CONR1, NR1CO, S, SO, SO2, O(CH2)p, p=1-3, (CH2)qO, n=1-3, cycloalkyl and heterocycloalkyl to link Ar1 and Ar2.
• Ar1, and Ar2 independently are a heteroaryl or aryl, each of which is substituted with from 0 to 4 substituents independently chosen from:
• (1) halogen, hydroxy, amino, cyano, —COOH, —SO2NH2, oxo, nitro and alkoxycarbonyl;
• and
• (2) C1-C6 alkyl, C1-C6alkoxy, C3-C10 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 alkanoyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, mono- and di-(C1-C6alkyl)amino, C1-C6 alkylsulfonyl, mono- and di-(C1-C6alkyl) sulfonamido and mono- and di-(C1-C6alkyl)aminocarbonyl;
• phenylC0-C4alkyl and (4- to 7-membered hetetocycle)C0-C4alkyl, each of which is substituted with from 0 to 4 secondary substituents independently chosen from halogen, hydroxy, cyano, oxo, imino, C1-C4allyl, C1-C4alkoxy and C1-C4haloalkyl.