Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors

A compound represented by the formula:

• or a pharmaceutically acceptable salt thereof, wherein
• R1 represents a hydrogen radical, —CH2SO2NH2, —CH2CO2CH3, —CO2CH3, —CONH2, —CH2C(O)NHCH3, —C(CH3)2(SH), —C(CH3)2(SCH3), —C(CH3)2(S[O]CH3), —C(CH3)2(S[O]2CH3), alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aminosulfonylalkyl, N-alkylaminosulfonylalkyl, N,N-dialkylaminosulfonylalkyl or heteroaralkyl, or a side chain of an amino acid selected from the group consisting of asparagine, lysine, aspartic acid, aspartic acid methyl ester, methionine or the sulfoxide or sulfone derivative thereof, S-methyl cysteine or the sulfoxide or sulfone derivative thereof, ornithine, leucine, isoleucine, norleucine, allo-isoleucine, alanine, phenylalanine, histidine, tert-leucine, glutamine, threonine, allo-threonine, serine, O-alkyl serine, beta-cyano alanine, and valine;
• R2 represents alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, each optionally substituted with one or more alkyl, halogen, —NO2, —CN, —CF3, —OR9 or —SR9, wherein R9 represents a hydrogen radical, alkyl, aryl, heteroaryl, cycloalkyl or heterocyclo;
• R3 represents hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclo, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, thioalkyl or the corresponding sulfone or sulfoxide derivative thereof, alkylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof, arylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof, aminoalkyl, or N-monosubstituted aminoalkyl or N,N-disubstituted aminoalkyl having one or two substituents independently selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocyclo and heterocycloalkyl;
• R4 represents alkyl, alkenyl, alkynyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclo, heterocycloalkyl, heteroaryl, heteroaralkyl, alkoxycarbonylaminoheteroaryl, aryl, aralkyl, aralkenyl, thioalkyl or the corresponding sulfone or sulfoxide derivative thereof, alkylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof, arylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof, aminoalkyl, or N-monosubstituted aminoalkyl or N,N-disubstituted aminoalkyl having one or two substituents independently selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocyclo, heterocycloalkyl, thioalkyl or the corresponding sulfone or sulfoxide derivative thereof, alkylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof, and arylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof;
• R6 represents a hydrogen radical or alkyl;
• each R7 independently represents a hydrogen radical, —CH2SO2NH2, —CH2CO2CH3, —CO2CH3, —CONH2, —CH2C(O)NHCH3, —(CH3)2(SH), —C(CH3)2(SCH3), —C(CH3)2(S[O]CH3), —C(CH3)2(S[O]2CH3), carboxy, amidino, N-alkylamidino, alkyl, aryl or aralkyl;
• or R7 together with R1 and the carbon atoms to which R7 and R1 are attached, represent cycloalkyl or heterocyclo;
• each R8 independently represents a hydrogen radical or alkyl;
• R10 represents a hydrogen radical, alkyl, aryl, aralkyl, heterocyclo, heterocycloalkyl, heteroaryl or heteroaralkyl;
• R11 represents a hydrogen radical, alkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclo, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heteroarylcarbonylalkyl, arylcarbonylalkyl, thioalkyl or the corresponding sulfone or sulfoxide derivative thereof, alkylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof, or arylthioalkyl or the corresponding sulfone or sulfoxide derivative thereof, aminoalkyl, or N-monosubstituted aminoalkyl or N,N-disubstituted aminoalkyl having one or two substituents independently selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocyclo and heterocycloalkyl;
• or R10 and R11 together with the nitrogen to which they are attached represent aralkylheteroaryl, aralkylheterocyclo, heteroaralkylheteroaryl or heteroaralkylheterocyclo radicals;
• x and w each independently represent 0, 1, or 2;
• t represents 0-4;
• and
• Y represents O, S or NH.