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US 2008/0176823 A1Published application
Breast and Prostate Cancer Treatment Method
AssigneeHollis-Eden Pharmaceuticals, Inc.
InventorsHenry A. Lardy, Padma Marwah, James M. Frincke
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Abstract
The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
Claims21
A method to treat a condition selected from the group consisting of prostate cancer, benign prostatic hyperplasia and breast cancer in a subject in need thereof, comprising administering an effective amount of a compound having the structure
- wherein,
- R5 is —OH, an ester, a carbonate or an ether and R6 is —H or alkynyl, or R6 is —OH, an ester, a carbonate or an ether and R5 is —H or alkynyl;
- R12 is —OH, —SH, an ester, a carbonate or an ether and R13 is —H or R12 is —H and R13 is —OH, —SH, an ester, a carbonate or an ether;
- R14 and R15 independently are —H, —OH, an ester or a carbonate;
- R16 and R17 independently are —H, —OH, an ester or a carbonate;
- R18 is —OH, an ester, a carbonate or an ether;
- R19 is alkynyl;
- R24 is —CH3 or —CH2OH;
- and
- R25 is —H, —CH3 or —CH2OH.
7 more elements
Dependencies are inferred from the claim text.