Carbocyclic nucleosides and process for obtaining such
AssigneeStichting Rega VZW
InventorsPiet Herdewijn, Jing Wang, Erik De Clercq
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AssigneeStichting Rega VZW
InventorsPiet Herdewijn, Jing Wang, Erik De Clercq
Estimating the term…
The present invention provides a six membered, at least partially unsaturated, carbocyclic nucleoside compound, including the (−) enantiomer, the (+) enantiomer, and pharmaceutically acceptable salts and esters thereof. The compounds are represented by formula (I), wherein Z represents one double bond in the six membered carbocylic ring, B is a heterocyclic ring, such as a pyrimidine or purine base, X is an azido, F or OR2, R1 and R2 are the same or different and represent the same or different protecting groups, hydrogen, alkyl, alkenyl, acyl or phosphate moieties, and wherein the alkyl moiety is a saturated, optionally unsubstituted hydrocarbon having from 1 to 20 carbon atoms, the alkenyl moiety is an unsaturated congener of the alkyl group, and the acyl moiety is analkanoyl or aroyl moiety.
A six membered, at least partially unsaturated, carbocyclic nucleoside compound, including the (−) enantiomer, the (+) enantiomer, and pharmaceutically acceptable salts and esters thereof, the compounds represented by formula I:
Process according to claim 19 wherein the diene has the following chemical structure XVI, and the dienophile has the following chemical structure XVII, wherein R1, R2, R3, R4, R5 and R6 are as defined in claim 20;
A six membered, at least partially unsaturated, carbocyclic nucleoside compound, including the (−) enantiomer, the (+) enantiomer, and pharmaceutically acceptable salts and esters thereof, the compounds represented by a formula selected from the group consisting of XII and XIX;
A cyclohexenyl compound, including the (−) enantiomer, the (+) enantiomer, and pharmaceutically acceptable salts and esters thereof, the compound represented by formula XVB;
Dependencies are inferred from the claim text.