Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
AssigneeNymox Pharmaceutical Corporation
InventorsPaul Averback, Jack Gemmell
Life of this patent
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Abstract
The embodiments include methods of treating conditions requiring removal or destruction of cellular elements, such as benign or malignant tumors in humans, using compounds based on small peptides. The method includes, but is not limited to, administering the compounds intramuscularly, orally, intravenously, intrathecally, intratumorally, intranasally, topically, transdermally, etc., either alone or conjugated to a carrier.
Claims19
An isolated peptide consisting of a fragment of a peptide consisting of the amino acid sequence in SEQ ID NO. 1 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu).
An isolated peptide comprising as least two fragments of a peptide consisting of the amino acid sequence in SEQ ID NO. 1 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu).
An isolated peptide comprising at least two repetitions of a fragment of a peptide consisting of the amino acid sequence in SEQ ID NO. 1 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu).
An isolated peptide comprising an amino acid in reverse-D order based on the amino acid sequence for a fragment of a peptide consisting of the amino acid sequence in SEQ ID NO. 1 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu).
An isolated peptide comprising a fragment of a peptide consisting of the amino acid sequence in SEQ ID NO. 1 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu) fused to an antibody, fragment of an antibody or an antibody-like molecule.
An isolated peptide comprising a fragment of a peptide consisting of the amino acid sequence in SEQ ID NO. 1 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu) and at least one and up to 25 additional amino acids flanking either the 3′ or 5′ end of the peptide, wherein said isolated peptide does not comprise the peptide consisting of the amino acid sequence in SEQ ID NO. 1 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu).
Dependencies are inferred from the claim text.