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AssigneeCorixa Corporation
InventorsAntonio Campos-Neto, Yasir Skeiky, Pamela Ovendale, Shyian Jen, Michael Lodes
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Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
An isolated polypeptide comprising an amino acid sequence of SEQ ID NO:146, 161, or 163, or an amino acid sequence comprising an immunogenic portion of an amino acid sequence of SEQ ID NO:146, 161, or 163.
An isolated polypeptide, wherein said polypeptide is encoded by a nucleotide sequence selected from the group consisting of SEQ ID NO:145, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 162, and 164, or an isolated polypeptide comprising an immunogenic portion of a polypeptide encoded by a nucleotide sequence selected from the group consisting of SEQ ID NO:145, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 162, and 164.
An isolated polynucleotide that specifically hybridizes under moderately stringent conditions to a second polynucleotide comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:145, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 162, and 164.
An isolated polynucleotide that specifically hybridizes under highly stringent conditions to a second polynucleotide comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:145, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 162, and 164.
Dependencies are inferred from the claim text.