Back to results
US 2008/0176788 A1Published application
Apo-2 ligand
AssigneeGenentech, Inc.
InventorsAvi J. Ashkenazi, Ralph H. Schwall
Life of this patent
Estimating the term…
Abstract
A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.
Claims21
An isolated soluble Apo-2 ligand polypeptide comprising amino acid residues 91-281 of FIG. 1A.
An isolated soluble Apo-2 ligand polypeptide consisting of amino acid residues 91-281 of FIG. 1A.
Dependencies are inferred from the claim text.