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US 2008/0176766 A1Published application
Methods and compositions involving mirna and mirna inhibitor molecules
AssigneeAsuragen, Inc.
InventorsDavid Brown, Lance Ford, Angie Cheng, Rich Jarvis, Mike Byrom, Dmitriy Ovcharenko, Eric Devroe, Kevin Kelnar
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Abstract
The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
Claims21
A synthetic RNA molecule of between 17 and 125 residues in length comprising
- a) an miRNA region whose sequence from 5′ to 3′ is identical to a mature miRNA sequence, and
- b) a complementary region whose sequence from 5′ to 3′ is between 60% and 100% complementary to the miRNA sequence.
-101. (canceled)
Dependencies are inferred from the claim text.