Systems and methods for biodosimetry with biochip using gene expression signatures
AssigneeThe Trustees of Columbia University in the City of New York, Office of the General Counsel
InventorsSally A. Amundson, Daniel Attinger, Chee Wei Wong
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Abstract
Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
Claims93
A device for determining radiation exposure of an organism comprising:
- (a) a microfluidic chip adapted to contain a biological sample from the organism;
- (b) a microlens coupled to the microfluidic chip;
- (c) an imaging element coupled to the microlens adapted to capture an image of the biological sample;
- and
- (d) a processor adapted to analyze the image for possible radiation exposure of the organism.
A method of determining radiation exposure of an organism comprising:
- (a) applying a light source to the microfluidic chip;
- (b) capturing an image of the microfluidic chip using an imaging element and a microlens wherein the microlens is coupled to the microfluidic chip;
- and
- (c) analyzing the image to determine radiation exposure of the organism.
A system for determining radiation exposure of an organism comprising:
- (a) illumination means for illuminating the microfluidic chip;
- (b) image capturing means for capturing an image of the microfluidic chip;
- (c) imaging means coupled to the microfluidic chip;
- (c) analyzing means for analyzing the image to determine radiation exposure of the organism.
Dependencies are inferred from the claim text.