Method for Suppressing Intermolecular Nonspecific Interaction and for Intensifying Intermolecular Specific Interaction on Metal Surface

A method of intensifying a specific interaction between a ligand and a target molecule, which comprises, in a process of immobilizing the ligand onto a metal surface and analyzing a specific interaction on the metal surface between the ligand and the target molecule of the ligand, a treatment to reduce the hydrophobic property of the metal surface.

A method of suppressing a nonspecific interaction between a ligand and/or a metal surface and a molecule other than a target molecule and intensifying a specific interaction between the ligand and the target molecule, which comprises, in a process of immobilizing the ligand onto the metal surface and analyzing a specific interaction on the metal surface between the ligand and the target molecule of the ligand, a treatment to reduce the hydrophobic property of the metal surface.

A method of suppressing a nonspecific interaction between a ligand and/or a metal surface and a molecule other than a target molecule, which comprises, in a process of immobilizing the ligand onto the metal surface and selecting a target molecule using a specific interaction on the metal surface between the ligand and the target molecule thereof, a treatment to reduce the hydrophobic property of the metal surface.

A method of intensifying a specific interaction between a ligand and a target molecule, which comprises, in a process of immobilizing the ligand onto the metal surface and selecting the target molecule using a specific interaction on the metal surface between the ligand and the target molecule thereof, a treatment to reduce the hydrophobic property of the metal surface.

A method of suppressing a nonspecific interaction between a ligand and/or a metal surface and a molecule other than a target molecule and intensifying a specific interaction between the ligand and the target molecule, which comprises, in a process of immobilizing the ligand onto the metal surface and selecting the target molecule using a specific interaction on the metal surface between the ligand and the target molecule thereof, a treatment to reduce the hydrophobic property of the metal surface.

A method of immobilizing a ligand onto a metal surface and analyzing a specific interaction on the metal surface between the ligand and a target molecule thereof which comprises suppressing a nonspecific interaction between the ligand and/or the metal surface and a molecule other than the target molecule by a treatment to reduce the hydrophobic property of the metal surface.

A method of immobilizing a ligand onto a metal surface and analyzing a specific interaction on the metal surface between the ligand and a target molecule thereof, which comprises intensifying a specific interaction between the ligand and the target molecule by a treatment to reduce the hydrophobic property of the metal surface.

A method of immobilizing a ligand onto a metal surface and analyzing a specific interaction on the metal surface between the ligand and a target molecule thereof, which comprises suppressing a nonspecific interaction between the ligand and/or the metal surface and a molecule other than the target molecule and intensifying a specific interaction between the ligand and the target molecule, by a treatment to reduce the hydrophobic property of the metal surface.

A method of immobilizing a ligand onto a metal surface, and selecting a target molecule using a specific interaction on the metal surface between the ligand and the target molecule thereof, which comprises suppressing a nonspecific interaction between the ligand and/or the metal surface and a molecule other than the target molecule by a treatment to reduce the hydrophobic property of the metal surface.

A method of immobilizing a ligand onto a metal surface, and selecting a target molecule using a specific interaction on the metal surface between the ligand and the target molecule thereof, which comprises intensifying a specific interaction between the ligand and the target molecule by a treatment to reduce the hydrophobic property of the metal surface.

A method of immobilizing a ligand onto a metal surface, and selecting a target molecule using a specific interaction on the metal surface between the ligand and the target molecule thereof, which comprises suppressing a nonspecific interaction between the ligand and/or the metal surface and a molecule other than the target molecule and intensifying a specific interaction between the ligand and the target molecule, by a treatment to reduce the hydrophobic property of the metal surface.

A solid phase carrier with a ligand immobilized thereon, which is a metal and has a hydrophilic spacer between the metal and the ligand.

A method of confirming introduction of a hydrophilic spacer between a ligand and a metal surface, which comprises, in a step of introducing the hydrophilic spacer between them during immobilization of the ligand onto the metal surface, detecting a leaving group produced by elimination of a protecting group derived from the hydrophilic spacer.