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US 2008/0176338 A1Published application
Labeling reactant
AssigneeWallac Oy
InventorsJari HOVINEN, Jari Peuralahti, Veli-Matti Mukkala
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Abstract
This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of said derivatives to bioactive molecules on solid phase in an oligopeptide synthesizer.
Claims6
A labeling reactant of formula (I)
- wherein:
- -A- is a linker formed from one to ten moieties, each moiety being selected from the group consisting of phenylene, alkyl containing 1-12 carbon atoms, ethynediyl (—C≡C—), ethylenediyl (—C═C—), ether (—O—), thioether (—S—), amide (—CO—NH— and —NH—CO— and —CO—NR″ and —NR″-CO—), carbonyl (—CO—), ester (—COO— and —OOC—), disulfide (—SS—), diaza (—N═N—) and tertiary amine (—NR″—), wherein R″ represents an alkyl containing less than 5 carbon atoms;
- R is independently —COOR′ or —CONHR′, wherein R′ is an alkyl of 1 to 4 carbon atoms, phenyl or benzyl, and wherein said phenyl or benzyl is substituted or unsubstituted;
- Z is a transient protecting group;
- and
- X is a carboxylic acid, or an organic or inorganic salt, active ester or acid halide thereof.
3 more elements
Dependencies are inferred from the claim text.