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US 2008/0176332 A1Published application
Systems and methods for identifying and disrupting cellular organelles
AssigneeThe Regents of the University of California
InventorsMichael W. Berns, Thoru Pederson
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Abstract
This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous nucleus in a cell.
Claims25
An optomechanical system comprising:
- a) a platform configured to accommodate at least one target object in a medium;
- b) a detector assembly functionally associated with the platform and configured to capture images of the target object or a portion thereof;
- c) at least one emitter functionally associated with the platform and configured to emit patterns of radiation suitable for:
- i) optically trapping the target object;
- and
- ii) disrupting the target object or portion thereof;
- d) a controller operatively associated with the detector assembly and the emitter, wherein the controller is configured to coordinate the pattern of radiation emission from the emitter with the image of the target object, or portion thereof, captured by the detector assembly.
4 more elements
A method comprising:
- a) directing a target object or portion thereof to a platform;
- b) imaging the target object or portion thereof;
- c) generating a profile of the target object or portion thereof based upon the image;
- and
- d) contacting the target object or portion thereof to radiation suitable for disrupting the target object or portion thereof, wherein the contacting comprises:
- i) emitting the radiation in a pattern determined by the profile of the object;
- ii) translocating the emitted radiation in a pattern determined by the profile of the object;
- or
- iii) maintaining the emitted radiation substantially stationary while translocating the object in a pattern determined by the profile of the object.
6 more elements
A method for identifying and disrupting a target object or portion thereof, the method comprising:
- a) directing a target object in to a platform;
- b) imaging a target object or portion thereof;
- c) outlining the image of the target object or portion thereof;
- d) generating a profile of the target object or portion thereof by digitizing the outlined image;
- e) transmitting the profile of the target object or portion thereof to an electronic controller operatively associated with an emitter;
- f) contacting the target object or portion thereof with radiation emission suitable for:
- i) optically trapping the target object or portion thereof;
- and
- ii) disrupting the target object or portion thereof.
6 more elements
Dependencies are inferred from the claim text.