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US 2008/0176308 A1Published application
Heterodimers and Methods of Using Them
AssigneeBiotechnology Research Corporation Limited
InventorsNancy Y. IP, Fanny Chui Fun IP, Yueqing Hu, Yifan Han, Sookja Kim Chung
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Abstract
Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.
Claims23
1-24. (canceled)
A compound of Formula I:
- wherein
- X1, X2 are independently selected from H, alkyl, halo, alkoxy;
- L1, L2, L3, L4 are bonds independently selected from bivalent Cl 5 alkylene;
- 1,4-cyclohexylene, 1,4-phenylene, —CO—, —O—, —S— and —NR—;
- R is selected from hydrogen, an unsubstituted or substituted alkyl, an unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkenyl, or unsubstituted or substituted aryl;
- with the proviso that if the tetrahydroquinolone is connected at 5-amino position, and L1-L2-L3-L4 is a C3-12 methylene linker, then one of X1 or X2 is not H.
3 more elements
Dependencies are inferred from the claim text.