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AssigneeCell Therapeutics, Inc.
InventorsDavid W. Leung, Philip A. Bergman, Alan Lofquist, Gregory E. Pietz, Christopher K. Tompkins, David W. Waggoner
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A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.
A recombinant fusion protein, comprising (i) a polyanionic polypeptide and (ii) a granulocyte colony stimulating factor at either one end or at both ends thereof, wherein the size of the polyanionic polypeptide is between 10 kD and 100 kD.
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A vector, comprising a cassette which comprises a nucleotide sequence that encodes (i) a polyanionic polymer, wherein the size of the polyanionic polypeptide when expressed is between 10 kD and 100 kD and (ii) granulocyte colony stimulating factor.
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Dependencies are inferred from the claim text.