HUMAN CYCLIN-DEPENDENT KINASE (hPNQALRE)
AssigneeChiron Corporation, a Delaware corporation
InventorChristoph Reinhard
Life of this patent
Estimating the term…
Abstract
A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.
Claims28
An isolated nucleic acid molecule comprising a nucleotide sequence at least 90% identical to a sequence selected from the group consisting of:
- a) SEQ ID NO:
- 1;
- b) SEQ ID NO:
- 3;
- c) SEQ ID NO:
- 5;
- d) SEQ ID NO:
- 7;
- e) nucleotides 76-114 of SEQ ID NO:
- 5;
- f) nucleotides 76-114 of SEQ ID NO:
- 7;
- g) nucleotides 503-564 of SEQ ID NO:
- 3;
- h) nucleotides 542-603 of SEQ ID NO:
- 5;
- i) nucleotides 542-603 of SEQ ID NO:
- 7;
- and
- j) the full complement of (a)-(i).
An isolated nucleic acid molecule comprising at least 15 contiguous nucleotides of a nucleotide sequence selected from the group consisting of:
- a) SEQ ID NO:
- 1;
- b) SEQ ID NO:
- 3;
- c) SEQ ID NO:
- 5;
- d) SEQ ID NO:
- 7;
- e) nucleotides 76-114 of SEQ ID NO:
- 5;
- f) nucleotides 76-114 of SEQ ID NO:
- 7;
- g) nucleotides 503-564 of SEQ ID NO:
- 3;
- h) nucleotides 542-603 of SEQ ID NO:
- 5;
- i) nucleotides 542-603 of SEQ ID NO:
- 7;
- and
- j) the full complement of (a)-(i).
The isolated nucleic acid molecule of claim 14 comprising at least 20 contiguous nucleotides of sequences (a)-(j).
An isolated nucleic acid molecule which hybridizes after washing with 0.2× SSC at 65° C. under highly stringent conditions to a nucleotide sequence selected from the group consisting of:
- a) SEQ ID NO:
- 1;
- b) SEQ ID NO:
- 3;
- c) SEQ ID NO:
- 5;
- d) SEQ ID NO:
- 7;
- e) nucleotides 76-114 of SEQ ID NO:
- 5;
- f) nucleotides 76-114 of SEQ ID NO:
- 7;
- g) nucleotides 503-564 of SEQ ID NO:
- 3;
- h) nucleotides 542-603 of SEQ ID NO:
- 5;
- i) nucleotides 542-603 of SEQ ID NO:
- 7;
- and
- j) the fall complement of (a)-(i).
An isolated nucleic acid molecule comprising a nucleotide sequence fully complementary to at least a portion of a nucleotide sequence selected from the group consisting of:
- a) SEQ ID NO:
- 1;
- b) SEQ ID NO:
- 3;
- c) SEQ ID NO:
- 5;
- d) SEQ ID NO:
- 7;
- e) nucleotides 76-114 of SEQ ID NO:
- 5;
- f) nucleotides 76-114 of SEQ ID NO:
- 7;
- g) nucleotides 503-564 of SEQ ID NO:
- 3;
- h) nucleotides 542-603 of SEQ ID NO:
- 5;
- i) nucleotides 542-603 of SEQ ID NO:
- 7;
- and
- j) the full complement of (a)-(i),
- said portion comprising at least 15 nucleotides.
An isolated nucleic acid molecule which encodes a protein having an amino acid sequence which is at least 90% identical to an amino acid sequence selected from the group consisting of SEQ I) NOS:2, 4, 6 and 8.
Dependencies are inferred from the claim text.