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US 2008/0176272 A1Published application
Assay device and method
AssigneeAmic AB
InventorsDavid BERGMAN, Ib MENDEL-HARTVIG, Simon UHRBERG
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AssigneeAmic AB
InventorsDavid BERGMAN, Ib MENDEL-HARTVIG, Simon UHRBERG
Estimating the term…
A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, wherein said substrate is a non-porous substrate, and at least part of said flow path consists of areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided adjacent to the zone for receiving the sample. Said means for separation are chosen among filter means, optionally enhanced by affinity binding and/or aggregation; magnetic means, also optionally enhanced by affinity binding and/or aggregation; and acoustic means.
A device for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, said device having a substrate comprising a zone for receiving the sample, optionally a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, characterized in that said substrate is a non-porous substrate, and at least part of said flow path comprises areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided within or adjacent to the zone for receiving the sample and wherein said means for separation comprises at least one filter.
A method for use in the detection of an analyte in a liquid sample, said detection taking place in a process on a substrate, where at least a subset of said sample is transported through capillary action from a receiving zone where said sample is added, to an optional zone where a reaction/detection takes place, said transport by capillary action defining a flow path, characterized in that said substrate is a non-porous substrate, at least part of said flow path comprises areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1,t2) such, that lateral capillary flow of said liquid sample is achieved, and that separation of unwanted components is performed without interruption of said capillary flow and wherein said separation is achieved using means for separation comprising a filter.
Dependencies are inferred from the claim text.