Biomarkers Of Metabolic Responses To Hepatotoxicants And Carcinogens
OwnerAlvin Berger, Imran A. Shahinventors
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Abstract
Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy.
Claims6
A method of determining whether a mammal has been exposed to hepatotoxant, the method comprising:
- analyzing a biological sample obtained from a mammal using one or more biomarkers selected from one or more biomarkers listed in Tables 1(a), 1(b), 2, and 3, and combinations thereof;
- and
- comparing the level(s) of the one or more biomarkers in the sample to levels of the one or more biomarkers from a control sample exposed to hepatotoxant;
- and
- determining whether the mammal has been exposed to hepatotoxant.
A method of determining whether a mammal has been exposed to PPAR affecting drug, the method comprising:
- analyzing a biological sample obtained from a mammal using one or more biomarkers selected from one or more biomarkers listed in Tables 1(a), 1(b), 2, and 3, and combinations thereof;
- and
- comparing the level(s) of the one or more biomarkers in the sample to levels of the one or more biomarkers from a control sample exposed to PPAR affecting drug;
- and
- determining whether the mammal has been exposed to PPAR affecting drug.
A method of determining whether a mammal has been exposed to clofibrate, the method comprising:
- analyzing a biological sample obtained from a mammal using one or more biomarkers selected from one or more biomarkers listed in Tables 1(a), 1(b), 2, and 3, and combinations thereof;
- and
- comparing the level(s) of the one or more biomarkers in the sample to levels of the one or more biomarkers from a control sample exposed to clofibrate;
- and
- determining whether the mammal has been exposed to clofibrate.
Dependencies are inferred from the claim text.