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US 2008/0176264 A1Published application
Osteoclast Culture Vessels and Methods of Use
OwnerDale Greenwaltinventor
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Abstract
Osteoclast culture vessels comprising and adherent layer of bone particles for detecting osteoclast function.
Claims30
An osteoclast culture vessel comprising at least one culture zone which comprises an adherent layer consisting essentially of bone particles which are less than about 0.15 mm in longest dimension.
A method of detecting osteoclast function comprising:
- examining culture medium of an osteoclast culture vessel to detect:
- (a) a moiety which reflects resorption of the bone particles;
- or
- (b) a marker of osteoclast differentiation,
- wherein the osteoclast culture vessel comprises at least one culture zone which comprises an adherent layer consisting essentially of bone particles which are less than about 0.15 mm in longest dimension and wherein the at least one culture zone further comprises culture medium and a population of osteoclasts or osteoclast precursors which overlie the adherent layer.
2 more elements
A method of making an osteoclast culture vessel, comprising:
- dispensing into a culture zone of a vessel a composition consisting essentially of water and bone particles which are less than about 0.15 mm in longest dimension, whereby upon evaporation of the water the culture zone comprises an adherent layer of the bone particles.
Dependencies are inferred from the claim text.