Method For Detecting Prp Using at Least One Positive Charge and/or at Least One Glycosidic Bond and a Ligand Other Than a Protein Ligand
AssigneesBiomerieux, Universite Claude Bernard Lyon, Centre National De La Recherche Scientifique, Agence Francaise De Securite Sanitaire Des Aliments
InventorsAnna Benscik-Reynier, Anthony William Coleman, Eric Da Silva, Marilyne Dupin, Edwige Leclere, Ambroise Martin, Aly Moussa, Herve Perron, Frederic Ronzon
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Abstract
The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic ligand selected from macrocyclic ligands and glycosaminoglycanes.
Claims17
A method for detecting PrP in a biological sample of human or animal origin that may contain said PrP, characterized in that it uses a molecule having at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand chosen from macrocyclic and glycosaminoglycan ligands.
A method for detecting PrP, in particular PrPsc, characterized in that it comprises the step consisting in bringing a biological sample, derived or obtained from an animal or human organism, into contact with a molecule having at least two guanidinium and/or ammonium functions, with the exception of the antibiotics.
A diagnostic kit for detecting PrP, characterized in that it comprises a ligand other than a protein ligand chosen from macrocyclic ligands and glycosaminoglycans, and a molecule having at least one positive charge and/or at least one glycosidic bond.
Dependencies are inferred from the claim text.