Gene regulator
AssigneeBiotempt B.V.
InventorsNisar Asmed Khan, Robert Benner
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Abstract
The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of a variety of diseases. The invention provides a method for modulating expression of a gene in a cell comprising providing the cell with a signalling molecule comprising a peptide or functional analogue thereof. Furthermore, the invention provides a method for identifying or obtaining a signalling molecule comprising a peptide or functional derivative or analogue thereof capable of modulating expression of a gene in a cell comprising providing the cell with a peptide or derivative or analogue thereof and determining the activity and/or nuclear translocation of a gene transcription factor.
Claims21
A method for identify a signaling molecule able to modulate expression of a gene in a cell, the method comprising:
- providing a first cell with a molecule comprising a peptide, peptide derivative, or peptide analogue, and
- determining relative up-regulation or down-regulation of at least one gene expressed in the first cell due to the molecule in comparison to a second cell not provided with the molecule,
- so as to identify a signaling molecule able to modulate expression of the gene in the cell.
Dependencies are inferred from the claim text.