Genes associated with schizophrenia
AssigneeSmithKline Beecham Corporation
InventorsStephanie Chissoe, Margaret G. Ehm, Pamela St. Jean
Life of this patent
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Abstract
Genes associated with schizophrenia are identified. Methods of screening small molecule compounds for use in treating schizophrenia are described.
Claims1
A method of screening a small molecule compound for use in treating schizophrenia, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by ADAMTS14, ADAMTS15, ADCY9, APCS, CACNA2D1, CD80, CFB/RDBP, CHRNA1, CREB1, CTSK, G30/DAOA, GABRA3, GRM5, HTR2C, IQGAP2/F2RL2, KCNB2, KCNH7, KCNJ14/GRWD1, KCNK13, MMP1, MMP16, NEFL, PAK7, PCAF, PROKR2, PTGDR, PTPRC, SMAD7, USP46, VDR, LVDLR, and WNT11, where activity against said target indicates the test compound has potential use in treating schizophrenia.
Dependencies are inferred from the claim text.