Non-invasive prenatal genetic screen
AssigneeBiocept, Inc.
InventorsRam Bhatt, Wen-Hua Fan, Roger Tim, Farideh Z. Bischoff
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Abstract
The present invention provides methods and kits useful for genetic testing or screening of fetuses using nucleic acid samples isolated from cervical mucus samples of fetus hosts.
Claims27
A method for conducting a genetic test of a fetus comprising
- isolating a nucleic acid sample from a cervical mucus sample obtained from a female subject containing the fetus,
- wherein the nucleic acid sample consisting essentially of polynucleotides in a size ranging from about 50 base pairs to about 300 base pairs and
- wherein the result of a genetic test on the nucleic acid sample is indicative of a genetic composition of the fetus.
A genetic testing kit suitable for testing genetic composition of a fetus comprising a pair of primers suitable for amplifying a desired allele or genetic marker, wherein the amplified nucleotide fragment is less than about 200 base pairs and wherein the desired allele or genetic marker is not uniquely associated with Y chromosome.
A genetic testing kit suitable for testing genetic composition of a fetus comprising an isolated DNA sample from a cervical mucus sample obtained from a female subject containing the fetus, wherein the DNA sample consisting essentially of polynucleotides in a size ranging from about 50 base pairs to about 200 base pairs.
An isolated DNA sample useful for genetic testing of a fetus obtained by isolating DNA fragments in a size ranging from about 50 base pairs to about 200 base pairs from a cervical mucus sample obtained from a female subject containing the fetus.
A method of isolating a fetal nucleic acid sample comprising:
- isolating a nucleic acid sample consisting essentially of polynucleotides of about 50 base pairs to about 300 base pairs in length from a cervical mucus sample obtained from a female subject containing the fetus.
Dependencies are inferred from the claim text.