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OwnerWilliam H. Andrews, Christopher Foster +2inventors
InventorsWilliam H. Andrews, Christopher Foster, Stephanie Fraser, Hamid Mohammadpour
Estimating the term…
Nucleic acid compositions comprising a region and a TERT minimal promoter activator binding site that acts to activate transcription of the telomerase reverse transcriptase (TERT) coding sequence, as well as vectors and constructs including the same, are provided. Also provided are methods of modulating, e.g., inhibiting, the TERT transcription activation activity of the subject TERT activator binding site regions in order to regulate, e.g., repress, telomerase expression, which methods find use in a variety of different applications, including the therapeutic applications and the like. In addition, methods of screening for agents that modulate the TERT transcription activating activity of the subject TERT activator sites are provided. The subject invention finds use in, among other applications, the regulation of TERT expression.
A nucleic acid present in other than its natural environment, wherein said nucleic acid has a nucleotide sequence that is the same as or substantially identical to a TERT activator binding site in the minimal TERT promoter.
-8. (canceled)
A method of repressing expression of TERT from a TERT expression system that includes a TERT promoter and a TERT activator binding site, said method comprising:
-27. (canceled)
A method of determining whether an agent Inhibits activation of TERT transcription, said method comprising:
-42. (canceled)
Dependencies are inferred from the claim text.