Method of predicting influenza outbreaks by correlating an increase in replikin count in shrimp white spot syndrome virus and/or taura syndrome virus
OwnerSamuel BOGOCH, Elenore S. BOGOCH +2inventors
InventorsSamuel BOGOCH, Elenore S. BOGOCH, Samuel Winston BOGOCH, Anne Elenore BORSANYI
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Abstract
The present invention provides a method of predicting outbreaks in influenza virus comprising monitoring concentrations of small peptides having defined structure in influenza viruses, and in particular viral pathogens of shrimp.
Claims21
A method of determining an increased probability of an outbreak of influenza virus within about one to about three years following an increase in Replikin concentration in an isolate of White Spot Syndrome Virus or an isolate of Taura Syndrome Virus comprising identifying said increase in the concentration of Replikin sequences in at least one first isolate of White Spot Syndrome Virus or Taura Syndrome Virus as compared to at least one other isolate of White Spot Syndrome Virus or Taura Syndrome Virus, wherein said at least one first isolate is isolated at least six months later than said at least one other isolate is isolated, and wherein when said at least one first isolate is a White Spot Syndrome Virus isolate said at least one other isolate is a White Spot Syndrome Virus isolate, and when said at least one first isolate is a Taura Syndrome Virus isolate said at least one other isolate is a Taura Syndrome Virus isolate, and wherein said increase in the concentration of Replikin sequences signifies the increased probability of the outbreak of influenza virus within about one to about three years following said increase in the concentration of Replikin sequences.
A computer readable medium having stored thereon instructions which, when executed, cause the processor to perform a method for predicting an outbreak of influenza virus comprising:
- (1) determining the Replikin concentration of amino acid or nucleic acid sequences of a plurality of isolates of a virus wherein said virus is present in a reservoir of influenza virus and wherein at least one first isolate has been isolated about six months to about three years later than at least one other of isolate;
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- (2) predicting an outbreak of influenza virus by identifying an increase in Replikin concentration in said at least one first isolate as compared to said at least one other of said plurality of isolates by comparing the Replikin concentrations of said at least one first isolate with said at least one other of said isolates wherein said outbreak of influenza virus is predicted to occur within about one to about three years from the time point at which said at least one first isolate was isolated.
A method of predicting an outbreak of influenza virus comprising:
- (1) obtaining a plurality of isolates of White Spot Syndrome Virus or a plurality of isolates of Taura Syndrome Virus wherein at least one of said isolates of White Spot Syndrome Virus is isolated about six months to about 3 years later than at least one other of said isolates of White Spot Syndrome Virus or wherein at least one of said isolates of Taura Syndrome Virus is isolated about six months to about 3 years later than at least one other of said isolates of Taura Syndrome Virus;
- (2) analyzing the amino acid sequence of at least one encoded protein or protein fragment or a combination of encoded proteins and/or protein fragments in each isolate of the plurality of isolates of White Spot Syndrome Virus or the plurality of isolates of Taura Syndrome Virus for the presence and concentration of encoded Replikin sequences;
- (3) comparing the concentrations of encoded Replikin sequences in the at least one protein or protein fragment or in the combination of proteins or protein fragments in each isolate of the plurality of isolates of White Spot Syndrome Virus or in each isolate of the plurality of isolates of Taura Syndrome Virus;
- (4) identifying an increase in the concentration of encoded Replikin sequences in said plurality of isolates of White Spot Syndrome Virus or in said plurality of isolates of Taura Syndrome Virus over at least one time period of about six months or greater;
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- (5) predicting an outbreak of influenza within about one to about three years following said identified increase in the concentration of Replikin sequences in said isolates of White Spot Syndrome Virus or in the concentration of Replikin sequences in said isolates of Taura Syndrome Virus.
A method of predicting an outbreak of influenza virus comprising:
- (1) obtaining a plurality of isolates of a first virus from at least one reservoir of Replikin sequences shared by influenza virus wherein the reservoir of Replikin sequences shared by influenza virus is any source of Replikin sequences that may be shared with an influenza virus including any host of influenza virus, any food source of a host of the influenza virus, any vector of influenza virus, or any substance wherein the genetic information of the influenza virus may be shared, mingled, mixed, exchanged or come into the proximity of the Replikin sequences of the reservoir;
- (2) analyzing the amino acid sequence of at least one encoded protein or protein fragment or a combination of encoded proteins and/or protein fragments in each isolate of the plurality of isolates of said first virus for the presence and concentration of encoded Replikin sequences;
- (3) comparing the concentrations of encoded Replikin sequences in the at least one protein or protein fragment or in the combination of proteins or protein fragments in each isolate of the plurality of isolates of said first virus;
- (4) identifying an increase in the concentration of encoded Replikin sequences in said plurality of isolates of said virus over at least one time period of about six months or greater;
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- (5) predicting an outbreak of influenza within about one to about three years following said identified increase in the concentration of Replikin sequences in said isolates of said first virus.
Dependencies are inferred from the claim text.