Reduction of Contaminants in Blood and Blood Products Using Photosensitizers and Peak Wavelengths of Light
AssigneeNavigant Biotechnologies, LLC
InventorsDennis J. HLAVINKA, Raymond P. GOODRICH, Heather REDDY
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Abstract
Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
Claims29
A method for reducing pathogens in a fluid containing red blood cells comprising;
- adding an isoalloxazine photosensitizer to the fluid to form a mixture, and
- exposing the mixture of the fluid and the photosensitizer to light within an approximate range of between 270-400 nm.
A method for reducing the formation of methemoglobin in a fluid containing red blood cells to be irradiated with UV light comprising the steps of;
- adding an isoalloxazine photosensitizer to the fluid to form a mixture, and
- exposing the mixture of the fluid and the photosensitizer to light within an approximate range of between 270-400 nm to create an irradiated fluid;
- wherein the formation of methemoglobin in the irradiated fluid is reduced.
A method for reducing the hemolysis of red blood cells to be irradiated with UV light comprising the steps of;
- adding an isoalloxazine photosensitizer to the fluid to form a mixture, and
- exposing the mixture of the fluid and the photosensitizer to light within an approximate range of between 270-400 nm to create an irradiated fluid;
- wherein hemolysis of red blood cells in the irradiated fluid is reduced to less then 0.4%.
A treatment chamber for reducing pathogens in a fluid containing red blood cells and a photosensitizer comprising:
- at least one radiation emitting source emitting radiation at a peak wavelength of approximately 302 nm;
- a support platform for holding the fluid containing red blood cells and photosensitizer to be irradiated;
- and
- a control unit for controlling the radiation emitting source.
(canceled)
Dependencies are inferred from the claim text.