Stem cell derived factors for treating pathologic conditions
AssigneesDuke University, The Brigham and Women's Hospital, Inc.
InventorsVictor Dzau, Maria Mirotsou
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Abstract
A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.
Claims10
A method of reducing cell death, comprising contacting an injured or diseased tissue with a composition comprising a purified paracrine factor of a mesenchymal stem cell (MSC), wherein said factor is a Secreted frizzled related protein (Sfrp).
The method enhancing cardiac tissue repair associated with a myocardial infarction, comprising contacting said tissue with a Sfrp polypeptide, wherein cardiac infarct size is reduced following contact of said tissue with said polypeptide.
Dependencies are inferred from the claim text.