Method for Decreasing Nicotine and Other Substance Use in Humans

A method of treatment of brain deterioration from ischemia-induced injury of brain tissue in a subject comprising an effective amount of tetrahydroberberine or analog thereof for attenuating ion channels in the brain tissue;

• and
• the effective amount of the tetrahydraberine or analog thereof is greater than 1 mg/kg body weight of the subject.

A method of treatment for reducing brain deterioration from ischemia-induced injury of brain tissue in a subject comprising an effective amount of tetrahydroberberine or analog thereof selected from the group consisting of 1-tetrahydropalmatine, 1-stepholidine and analogs thereof for inserting into ion channels whereby reducing ischemia-induced injury of the brain tissue;

• and
• the effective amount of the tetrahydraberine or analog thereof is greater than 1 mg/kg body weight of the subject.

A method of treatment of brain deterioration from ischemia-induced injury in a subject comprising an effective amount of a Corydalis, Stephania or Fibraurea plant to the subject for treating brain deterioration by blocking ion channels in the brain of the subject;

• the effective amount of the Corydalis, Stephania or Fibraurea plant includes a plant compound selected from the group consisting of tetrahydroberberine, 1-tetrahydropalmatine, and I-stepholidine for attenuating brain deterioration in the subject;
• and
• the effective amount of the Corydalis, Stephania or Fibraurea plant is greater than 1 mg/kg body weight of the subject.

A method of attenuating brain tissue deterioration from ischemia-induced injury in a subject, which comprises the step of administering an effective amount of a Corydalis, Stephania or Fibraurea plant to the subject;

• and
• the effective amount of the Corydalis, Stephania or Fibraurea plant provides a plant compound selected from the group consisting of tetrahydroberberine, itetrahydropalmatine, and I-stepholidine for blocking ion channels in a brain of the subject.