Methods and Compositions Related to Regulation of Cytokine Production by Glycogen Synthase Kinase 3 (Gsk-3)
OwnerMichael Martininventor
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Abstract
This invention relates generally to a method of treating inflammation and associated diseases and disorders by administering an agent that inhibits glycogen synthase kinase 3 activity.
Claims29
A method of reducing the severity of inflammation in a subject comprising:
- a. selecting a subject with inflammation or at risk for inflammation and
- b. administering to the subject an effective amount of an agent that inhibits glycogen synthase kinase 3 activity, inhibition of glycogen synthase kinase 3 reducing the severity of inflammation in the subject.
A method of reducing the severity of inflammation in a subject comprising:
- a. selecting a subject with inflammation or at risk for inflammation and
- b. administering to the subject an effective amount of an agent that inhibits phosphorylation of glycogen synthase kinase 3 activity, inhibition of phosphorylation of glycogen synthase kinase 3 reducing the severity of inflammation in the subject.
A method of reducing the severity of inflammation in a biological system comprising:
- a. selecting an inflamed biological system or a biological system at risk for inflammation and
- b. administering to the biological system an effective amount of an agent that inhibits glycogen synthase kinase 3, inhibition of glycogen synthase kinase 3 reducing the severity of inflammation in the biological system.
A method of reducing the severity of inflammation in a biological system comprising:
- a. selecting an inflamed biological system or a biological system at risk for inflammation and
- b. administering to the biological system an effective amount of an agent that modulates phosphorylation of glycogen synthase kinase 3, modulation of phosphorylation of glycogen synthase kinase 3 reducing the severity of inflammation in the biological system.
A method of reducing the severity of inflammation in a subject comprising:
- a. selecting a subject with inflammation or at risk for the inflammation and
- b. administering to the subject an effective amount of an agent that inhibits phosphorylation of glycogen synthase kinase 3, inhibition of phosphorylation reducing the severity of the inflammation in the subject.
A method of reducing the risk of inflammation in a recipient of an implantation or a transplantation comprising contacting the implant or transplant with an agent that inhibits glycogen synthase kinase 3 activity, inhibition of glycogen synthase kinase 3 activity reducing the risk of inflammation of the recipient.
A method of reducing the risk of inflammation in a recipient of an implantation or a transplantation comprising contacting the implant or transplant with an agent that modulates phosphorylation of glycogen synthase kinase 3 activity, modulation of phosphorylation of glycogen synthase kinase 3 activity reducing the risk of inflammation of the recipient.
Dependencies are inferred from the claim text.