Back to results
US 2008/0175918 A1Published application
Chemically cross-linked elastomeric microcapsules
OwnerBryan E. Laulichtinventor
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerBryan E. Laulichtinventor
Estimating the term…
The present invention relates to the fields of stably encapsulating oral care, skin care, scented, flavoring agents for cued release, and therapeutic agents for extended and sustained release. The invention relates to the stable microencapsulation of these agents for incorporation into dentifrices, topical ointments, microwavable food products, dryer sheets and chewing gums to be released during brushing, applying, heating, tumbling, and masticating respectively. Additionally, the invention encompasses extended and sustained release formulations that achieve reservoir-type delivery of therapeutic agents. The invention discloses methods for manufacturing and post-processing populations of chemically cross-linked elastomeric microcapsules allowing for the incorporation of encapsulated agents into a wide range of formulations without significantly altering their physio-chemical properties while providing for the cued delivery of the encapsulated agent upon the reception of a single or multiple mechanical or thermo-mechanical cues, or extended delivery via diffusion.
A population of microcapsules comprising:
A method of forming a population of microcapsules, in which the method comprises emulsifying the encapsulated phase within a dual-component encapsulant phase comprising a pre-polymer and curing agent, and emulsifying both phases within a third, aqueous phase.
A method of forming a population of microcapsules, in which the method comprises emulsifying the encapsulated phase within a multi-component encapsulant phase comprising a pre-polymer, a curing agent, and a carrier solvent, and emulsifying both phases within a third, aqueous phase, enabling carrier solvent evaporation.
A method of forming a population of microcapsules, in which thermally-sensitive active agents are encapsulated at or below about 30° C. utilizing a room temperature vulcanizing pre-polymer and curing agent.
A method of forming a population of microcapsules, in which the pre-polymer and curing agents are cured at a temperature greater than about 30 but less than about 100° C.
A method for producing chemically cross-linked elastomeric microcapsules containing a high osmolarity solution, wherein the high osmolarity is achieved by encapsulating an inactive agent within the encapsulated phases in addition to the active agent, wherein the inactive agent is selected from the group consisting of osmolarity-increasing, viscosity-increasing, and surface-active agents.
Dependencies are inferred from the claim text.