Pharmaceutical dosage forms for controlled release producing at least a timed pulse
AssigneeSanofi-Aventis
InventorsFrederic ANDRE, Gareth LEWIS, Jerome MIGNONNEAU, Agnes RIBARDIERE
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Abstract
The present invention relates to delayed release coated cores comprising an active substance in their core and a polymer coating comprising at least one or more ammonio methacrylate copolymer, characterized in that the core comprises at least a surfactant; to monolithic or multiparticulate pharmaceutical dosage forms comprising such delayed release coated cores and to their method of manufacture.
Claims29
A delayed release coated core which produces a timed pulse release containing an active substance in its core and a polymer coating comprising an ammonio methacrylate copolymer, said core further containing a zwitterionic surfactant in an amount of from 10% to 50% relative to the amount of ammonio methacrylate copolymer in the coating, and wherein the zwitterionic surfactant is chosen from N-alkylbetaines, C-alkylbetaines, N-alkylamidobetaines and N-alkylglycines.
Dependencies are inferred from the claim text.