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AssigneeOsmotica Corp.
InventorsJuan A. VERGEZ, Joaquina FAOUR, Marcelo A. RICCI, Ana C. PASTINI
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The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-Alzheimer's or an anti-Parkinson's drug in a rapid release external coat. Memantine is used as an anti-Alzheimer's drug or an anti-Parkinson's drug. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One embodiment of the osmotic device includes an external coat that has been spray-coated rather than compression-coated onto the device. The device is useful for the treatment of symptoms associate with Alzheimer's disease and/or Parkinson's disease patients. The device and method can also be used to treat or ameliorate other symptoms associated with Alzheimer's disease, Parkinson's disease or any other neurological disorder. Other dosage forms that provide a controlled, sustained or extended release of venlafaxine in combination with a rapid or immediate release of memantine are useful in the invention.
A method of ameliorating one or more symptoms associated with Alzheimer's disease and/or Parkinson's disease in a subject, the method comprising the steps of:
A method of ameliorating one or more symptoms associated with vascular dementia, HIV dementia, multiple sclerosis, drug dependence, epilepsy diabetic neuropathy, neuropathic pain, age associated memory impairment, and chronic pain in a subject, the method comprising the steps of:
Dependencies are inferred from the claim text.