System, devices, and methods for iontophoretic delivery of compositions including antioxidants encapsulated in liposomes
OwnerKentaro Kogure, Moeko Miyashita +1inventors
InventorsKentaro Kogure, Moeko Miyashita, Hideyoshi Harashima
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Abstract
Systems, devices, and methods for delivering one or more active ingredients to intradermal tissues, deep regions of pores, and intradermal tissues in the vicinity of the pores. In some embodiments, a composition is provided including a plurality of liposomes including a cationic lipid, and an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety, and one or more antioxidants and/or antioxidant enzymes.
Claims34
A composition for iontophoretic delivery of one or more antioxidant enzymes, comprising:
- a plurality of liposomes comprising:
- a cationic lipid, and
- an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety;
- and
- one or more antioxidant enzymes selected from the group consisting of superoxide dismutase (SOD), glutathione peroxydase (GSH-Px), and catalase, the one or more antioxidant enzymes being carried by the liposomes.
A method for treating a condition or a disease associated with oxidative stress in a living biological subject comprising:
- iontophoretically administering to the living biological subject a composition comprising a plurality of liposomes comprising a cationic lipid, an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety, and one or more antioxidant enzymes selected from the group consisting of superoxide dismutase (SOD), glutathione peroxydase (GSH-Px), and catalase, the one or more antioxidant enzymes being carried by the plurality of liposomes, the cationic lipid present in a molar ratio of the cationic lipid to the amphiphilic glycerophospholipid of about 3:7 to about 7:3, and the liposome having an average particle diameter ranging from about 400 to about 1000 nm;
- and
- providing a sufficient amount of current to deliver a therapeutic effective amount of the composition to the living biological subject.
A method for preventing oxidative damage in a biological subject comprising:
- iontophoretically administering to the biological subject in need of such treatment a therapeutically effective amount of a composition comprising a plurality of liposomes comprising a cationic lipid, an amphiphilic glycerophospholipid having a saturated fatty acid moiety and an unsaturated fatty acid moiety, and one or more antioxidant enzymes selected from the group consisting of superoxide dismutase (SOD), glutathione peroxydase (GSH-Px), and catalase, the cationic lipid present in a molar ratio of the cationic lipid to the amphiphilic glycerophospholipid of about 3:7 to about 7:3, and the one or more antioxidant enzymes being carried by the plurality of liposome.
Dependencies are inferred from the claim text.