Methods of treating neurological conditions with hematopeitic growth factors

A method of treating a neurological condition in a mammal in need thereof, comprising contacting a neural stem cell composition with a hematopoietic factor selected from the group consisting of GCSF, GMCSF, IL-3, IL-5, a derivative thereof, a mimetic thereof, and a combination thereof;

• and subsequently administering the neural stem cells to the mammal.

A method of enhancing the survival of a cell transplanted into a mammal, comprising introducing into the cell one or more polynucleotides which encode a hematopoietic factor selected from the group consisting of IL-3, IL-5, a derivative thereof, a mimetic thereof, and a combination thereof, wherein the cell expresses the hematopoietic factor in an amount sufficient to enhance the survival of the cell relative to the cell survival prior to introducing the one or more polynucleotides.

A method of enhancing the viability of a neural cell culture comprising contacting the neural cell culture with a hematopoietic factor selected from the group consisting of IL-3, IL-5, a derivative thereof, a mimetic thereof, and a combination thereof in an amount sufficient to enhance the viability of the neural cell culture relative to the culture prior to contacting with the hematopoietic factor.

A method of enhancing the viability of a neural cell culture comprising introducing one or more polynucleotides into the cells of the neural cell culture wherein the polynucleotide is expresses a hematopoietic factor selected from the group consisting of IL-3, IL-5, a derivative thereof, a mimetic thereof, and a combination thereof, and wherein the polynucleotide expresses the hematopoietic factor in an amount sufficient to enhance the viability of the neural cell culture relative to the culture prior to contacting with the hematopoietic factor.

A method for enhancing the cognitive ability of a mammal in need thereof, comprising administering a hematopoietic factor selected from the group consisting of IL-3, IL-5, a derivative thereof, a mimetic thereof, and a combination thereof in an amount sufficient to enhance the cognitive ability of a mammal relative to the mammal prior to the administrating.