Gas-containing liposomes
AssigneeNorthwestern University
InventorsShaoling Huang, Robert C. MacDonald, Patrick Kee, David McPherson
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Abstract
The present invention provides gas-containing liposomes. In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (e.g., 10 ul of gas per 5 mg of gas-containing liposomes). In certain embodiments, the gas-containing liposomes contain nitric oxide gas. In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (e.g., intimal hyperplasia).
Claims22
A method of making a gas-containing liposome, comprising:
- freezing under pressure, liposomes with gas, to generate a gas-liposome dispersion;
- and thawing said gas-liposome dispersion to generate a plurality of gas-containing liposomes.
A composition comprising a plurality of gas-containing liposomes, wherein said gas-containing liposomes comprise at least 15 ul of gas per 5 mg of said gas-containing liposomes.
A method of treating a medical condition comprising:
- administering a composition to a patient, wherein said composition comprises a plurality of liposomes, wherein said liposomes comprise gas;
- wherein said patient has a medical condition that is at least partially treatable by said gas;
- and wherein said administering is under conditions such that said gas is released in said patient.
A method of treating a patient comprising:
- administering a composition to a patient, wherein said composition comprises a plurality of liposomes, wherein said liposomes comprise gas and a therapeutic agent.
Dependencies are inferred from the claim text.